Decoding
Bacterial
Resistance
From Molecular Mechanisms to
Therapeutic Innovation.
Laboratory Feature
Team Hazra Lab
The Hazra Group Mission
The Hazra Group is a multidisciplinary research laboratory driven by a singular mission: confronting the growing global crisis of antimicrobial resistance (AMR). At the heart of our work lies a deep curiosity about how bacteria survive, adapt, and evolve under therapeutic pressure.
Our research spans the interface of structural biology, enzymology, computational science, and translational microbiology. By combining protein crystallography, enzyme kinetics, biophysical characterization, structure–function analysis, and AI-assisted computational approaches, we seek to uncover the mechanistic principles that govern bacterial resistance.
"A major focus of the laboratory is the study of β-lactamases and other clinically important resistance determinants, as well as enzymes involved in peptidoglycan biosynthesis and essential bacterial survival pathways."
Lab Highlights
Join Our Mission
Motivated PhD & Postdoc candidates are always welcome to apply.
View Open Positions →Updates
May 1:Congratulations Riya for submitting PhD Thesis
Laboratory Impact
Bridging Atomic Discovery
with Global Health Solutions.
Structural Biology
Unlocking atomic-level blueprints of bacterial enzymes using X-ray crystallography.
Enzymatic Mechanisms
Decoding biochemical pathways that allow pathogens to neutralize antibiotics.
Computational Design
Leveraging AI and MD simulations to rationally design the next generation of inhibitors.
150+
Publications
Journal articles
4+
Patents
Innovations
15+
Alumni
PhD Scholars
110L+
Grants
Total funding
Driven by Innovation, Defined by Impact.
Established in 2014 at the Department of Bioscience and Bioengineering, IIT Roorkee.
Biochemistry (ACS Publications)
2026
Thermodynamic and Allosteric Drivers of Stilbene-Mediated Noncompetitive Inhibition of Firefly Luciferase
Photinus pyralis luciferase (Ppy luci) is widely used as a reporter molecule in high-throughput assays for biochemical, cell viability, and cellular pathway studies. Resveratrol is a naturally occurring stilbene compound known to inhibit luminescence emission catalyzed by Ppy luci. Although it has been identified as an inhibitor, its detailed mechanism has not been investigated. In the present work, three stilbene compounds (piceatannol, resveratrol, and pterostilbene) were studied for their luminescence inhibition properties to determine the factors underlying inhibition and the role of functionalization. QSAR analysis, followed by steady-state kinetics, suggested an allosteric mode of inhibition by stilbene inhibitors, with piceatannol showing the highest potency. Isothermal titration calorimetry, docking, and MMPBSA/MMGBSA supported the inhibition assay, wherein the piceatannol have a higher binding affinity compared to pterostilbene, driven by enthalpic contributions.
Citation Details
Biochemistry (ACS Publications) • 2026