Hazra Lab

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Gazal Kalyan

Gazal Kalyan

alumni

Fellowship: PMRF, MHRD

Biography

Integrated M.Tech in Nanotechnology, Central University of Jharkhand :

About My Work
Working on developing BRET-FRET nanosensors for detection of beta lactamase enzymes using modified luciferase protein.

Academic Background

Integrated M.Tech in Nanotechnology, Central University of Jharkhand | 2016-2021,

Selected Publications

  1. ASR. Nair; A. Samanta, S. Hazra; “Understanding the basis of thermostability for enzyme Nanoluc towards designing industry-competent engineered variants”; Journal of Biomolecular Structure and Dynamics, 43(18), 10328–10341. https://doi.org/10.1080/07391102.2024.2319675,
  2. ASR. Nair; K. Dhankhar, D. Singh A. Samanta, S. Hazra; “Biophysical Mapping of β-Lactamase–AuNP Conjugates: Mechanisms and Metrics for High- Resolution AMR Detection”, Journal of Biomedical Engineering and Biosciences,12 (1), 98-106, 10.11159/jbeb.2025.012, Part of thesis
  3. ASR. Nair; A. Samanta, S. Hazra; “Revolutionizing DNAzyme Biosensors: Pioneering Strategies, Advanced Immobilization, Versatile Applications, and Future Frontiers”, ACS Synthetic Biology, ACS Synthetic Biology 14 (11), 4163-4177, https://doi.org/10.1021/acssynbio.5c00074,
  4. Kumar; ASR. Nair; S. Sharma; D. Singh; D. Bhimsaria; S. Gupta; S. Hazra; “Strategic Design of a Multi-Tier Database for Class A β-Lactamase BlaC Variants of M. tuberculosis: Advancing the Fight Against Antibacterial Resistance”, The Journal of Antibiotics ,J Antibiot 78, 757–772 (2025). https://doi.org/10.1038/s41429-025-00862-3
  5. K. Dhankhar, ASR. Nair, M. Hazra, A. E. A. Alkhatib, S. Baidya, N. C. Mishra, S. Hazra; “Structural insights into the role of cyclopropyl stereochemistry on the inhibitory activity of Xeruborbactam against SME-1 class A carbapenemase”, Biochemistry,64, 19, 4217–4231, https://doi.org/10.1021/acs.biochem.5c00336
  6. K. Dhankhar,, M. Hazra, ASR. Nair, A. E. A. Alkhatib, N. C. Mishra, S. Hazra; Beyond structure and activity: Targeting Class A Carbapenemase with Monocyclic and Bicyclic Boronic Acids to Counter AMR, Org. Biomol. Chem., 2026,24, 1595-1599,, https://doi.org/10.1039/D5OB01703C
  7. Kumar, ASR. Nair, V. Arya, S. Yadav, S. Bhattacharya, A. Mangaraj, D. Bhimsaria, S. Gupta, S. Hazra, “A Multi-Tier Integrative Database of Bla Mab Variants Reveals Mutational Landscapes and Resistance Determinants in Mycobacterium abscessus”, (Manuscript under preparation)

Posters & Conferences

  1. Poster presentation, ASR.Nair; K.Dhankhar, A. Samanta, S. Hazra; "Biophysical Insights into β-Lactamase-Gold Nanoparticle Conjugates:Pioneering Diagnostic Solutions for Antimicrobial Resistance”, 11th International Conference on Bioengineering and Biotechnology, Paris, France
  2. Poster presentation, ASR.Nair; Nupur Sajjan, A. Samanta, S. Hazra; "Unveiling the Molecular Enigma: Characterization and Engineering of Photinus pyralis Luciferase for Next-Generation Antibacterial Resistance (ABR) Detection Kits" Sagamore XX, Shiv Nadar University, Noida
  3. Poster presentation, ASR.Nair; A. Samanta, S. Hazra; "Exploring the biophyiscal and spectroscopic properties of β-lactamase - gold nanoparticle conjugates targeting antimicrobial resistance diagnstics; Indo-Japan Symposium on Nanotheranotics (InJaNa 2024), Indian Institute of Technology (IIT), Roorkee
  4. Poster presentation, ASR.Nair; A. Samanta, S. Hazra; “Comprehensive spectroscopic study of β-lactamase-gold nanoparticle conjugates towards development of diagnostic device against AMR” , 8th International Conference on Advanced Nanomaterials and Nanotechnology, Indian Institute of Technology (IIT), Guwahati
  5. Poster presentation, ASR.Nair; A. Samanta, S. Hazra; “Comprehensive biophysical study of β-lactamase-gold nanoparticle conjugates towards development of diagnostic device against AMR”, 50th National Seminar on Crystallography, CSIR- Institute of Microbiology Technology, Chandigarh
  6. Poster presentation, ASR.Nair; A. Samanta, S. Hazra; “Multilevel structural and dynamic analysis of Nanoluciferase enzyme for its better understanding for sensitive detection of enzyme β-lactamase through SRET devices”, 49th National Seminar on Crystallography, Jammu University
  7. Oral presentation, ASR.Nair; A. Samanta, S. Hazra; "Multi-level In-silico study of enzyme Nanoluc towards higher thermal stability helps in developing robust SRET based diagnostics" International Interdisciplinary conference on energy, nanotechnology, and internet of things (IoT), NIT Puducherry